Peripheral atherosclerosis diagnostics by the circulating biomarkers determination

Abstract

Lower extremities atherosclerosis – severe disabling disease, which leads to ischemia of the extremities. Peripheral atherosclerosis is the main cause of non-traumatic amputations. Due to different clinical features or asymptomatic, the disease is often underdiagnosed at the early stages and the treatment is initiated already in severe defeat when only surgery allows the limb salvage. Currently there is a strong need for specific biomarkers of peripheral atherosclerosis determination. Diagnosis of peripheral atherosclerosis by analyzing blood in the early stages is easier and cheaper than instrumental examination and can help prescribe adequate treatment to prevent severe complications