Adiponectin, dyslipoproteinemia, insulin: the relationship and impact on the risk of angina recurrence in men after myocardial revascularization

Abstract

Aim. The aim of this study was to examine the relationship of adiponectin levels with other hormonal and metabolic parameters and their influence on the risk of early recurrent angina in patients with coronary artery disease after myocardial revascularization.
Materials and methods. The study included 101 patients with coronary artery disease (CAD), male from 35 to 65 years (mean age 52,4±7,5 years).
Results. All patients underwent surgery coronary artery bypass grafting without cardiopulmonary bypass. Patients were divided into three groups according to the level of adiponectin (tertiles). Independent associations with adiponectin levels hormonal and metabolic parameters were identified. The most significant negative correlation was identified between the levelsof adiponectin and triglycerides (r=—0,36; p=0,043), levelsof stimulated insulinemia (r=—0,40; p=0,02) and glucose level 120 min after loading (r=—0,36; p=0,039). Adiponectin was the only one factor associated with insulin resistance, which influenced the clinical outcome during the year after surgery.

Conclusion. Definition of early predictors and markers of abdominal aortic calcification can significantly affect the individual treatment program that will certainly influence on the outcome of both conservative and surgical treatment of peripheral atherosclerosis