Изучение рентгеноморфологических особенностей ахиллова сухожилия у мужчин с атеросклерозом различной локализации.

A. V. Anikina; L. V. Shcherbakova; M. E. Amelin; Yu. I. Ragino

doi:10.34687/2219-8202.JAD.2022.04.0004

Authors

A. V. Anikina The Institute of Internal and Preventive Medicine – a branch of a federal publicly funded scientific institution «The Federal research center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences» https://orcid.org/0000-0002-9086-6291
L. V. Shcherbakova The Institute of Internal and Preventive Medicine – a branch of a federal publicly funded scientific institution «The Federal research center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences»
Mikhail E. Amelin Novosibirsk Federal Neurosurgical Center
Yu. I. Ragino The Institute of Internal and Preventive Medicine – a branch of a federal publicly funded scientific institution «The Federal research center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences»

DOI:

https://doi.org/10.34687/2219-8202.JAD.2022.04.0004

Keywords:

atherosclerosis, dyslipidemia, xanthomatosis, computed tomography.

Abstract

Abstract.

The results of the literature data emphasize the need to observe and combine data to assess the prognostic value of the presence of xanthus for the development of the atherosclerotic process. Studies using CT angiography suggest that xanthomas may be a significant marker of increased risk of cardiovascular diseases.

Objective: to study the X-ray morphological features of the Achilles tendon in men with atherosclerosis of various localization by multispiral computed tomography.

Materials and methods.

The main group of the study consisted of 90 men aged 50-68 years who, according to multispiral computed tomography, had atherosclerosis of the vascular wall of at least 1 localization. The control group included men of comparable age, in whom, according to instrumental diagnostic methods, no atherosclerotic lesion was detected (n=40 men).

The main study group was divided into 2 subgroups. The first group consisted of patients with multifocal atherosclerosis of various localizations, confirmed by computed tomography data (n=56 men). The second group consisted of patients with isolated atherosclerotic lesions of the carotid arteries (n=34 men).

Results.

It was revealed that the levels of total blood cholesterol (OHC), low-density lipoprotein cholesterol (LDL-C), triglycerides were higher in men with multifocal atherosclerosis than in the group with isolated lesions of brachiocephalic arteries by 1.1 times; 1.3 times; 1.4 times, respectively. In men with widespread atherosclerotic vascular lesion, the cross-sectional area and density of the Achilles tendon were 1.1 times higher than in men with isolated atherosclerotic lesion.

It was revealed that the blood levels of OHC, LDL-C were higher, and the level of HDL-C was lower in individuals with isolated atherosclerosis of the carotid basin than in men without atherosclerosis by 1.1 times.

Conclusion.

Patients with higher cholesterol and its fractions and widespread atherosclerosis of the arteries had the largest cross-sectional area and density of Achilles tendon tissue.

Downloads

Download data is not yet available.

Author Biographies

L. V. Shcherbakova, The Institute of Internal and Preventive Medicine – a branch of a federal publicly funded scientific institution «The Federal research center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences»

Senior researcher in the Laboratory of Clinical, Population and Preventive Studies of Therapeutic and Endocrine Diseases

Mikhail E. Amelin, Novosibirsk Federal Neurosurgical Center

Head of the Radiology Department

Yu. I. Ragino, The Institute of Internal and Preventive Medicine – a branch of a federal publicly funded scientific institution «The Federal research center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences»

A corresponding member of the Russian Academy of Sciences, PhD, MD, Professor, Head of IIPM – Branch of IC&G SB RAS,

References

Józsa L, Réffy A, Bálint JB. The pathogenesis of tendolipomatosis; an electron microscopical study. Int Orthop. 1984;7(4):251-5. doi: 10.1007/BF00266836. PMID: 6746169

Tsouli SG, Kiortsis DN, Argyropoulou MI, Mikhailidis DP, Elisaf MS. Pathogenesis, detection and treatment of Achilles tendon xanthomas. Eur J Clin Invest. 2005 Apr;35(4):236-44. doi: 10.1111/j.1365-2362.2005.01484.x. PMID: 15816992

Abate M, Schiavone C, Salini V, Andia I (2013) Occurrence of tendon pathologies in metabolic disorders. Rheumatology 52(4):599–608

Abate M, Di Carlo L, Salini V, Schiavone C (2014) Metabolic syndrome associated to non-inflammatory Achilles enthesopathy. Clin Rheumatol 33(10):1517–22

Soslowsky LJ, Fryhofer GW. Tendon Homeostasis in Hypercholesterolemia. Adv Exp Med Biol. 2016;920:151-65. doi: 10.1007/978-3-319-33943-6_14. PMID: 27535257

Tada H, Okada H, Nomura A, Usui S, Sakata K, Nohara A, Yamagishi M, Takamura M, Kawashiri MA. Clinical Diagnostic Criteria of Familial Hypercholesterolemia - A Comparison of the Japan Atherosclerosis Society and Dutch Lipid Clinic Network Criteria. Circ J. 2021 May 25;85(6):891-897. doi: 10.1253/circj.CJ-20-0901. Epub 2020 Dec 3. PMID: 33268660

Забавская О.А., Ваза А.Ю., Шарифуллин Ф.А. и др. Компьютерная томография в диагностике повреждений проксимального отдела голени // Журнал им. Н.В. Склифосовского Неотложная медицинская помощь.–2016. – No 4. – С.61–66

Ogura M, Harada-Shiba M, Masuda D, Arai H, Bujo H, Ishibashi S, Daida H, Koga N, Oikawa S, Yamashita S; FAME Study Group. Factors Associated with Carotid Atherosclerosis and Achilles Tendon Thickness in Japanese Patients with Familial Hypercholesterolemia: A Subanalysis of the Familial Hypercholesterolemia Expert Forum (FAME) Study. J Atheroscler Thromb. 2021 Jun 10. doi: 10.5551/jat.62925. Epub ahead of print. PMID: 34108342

Michikura M, Ogura M, Hori M, Matsuki K, Makino H, Hosoda K, Harada-Shiba M. Association between Achilles Tendon Softness and Atherosclerotic Cardiovascular Disease in Patients with Familial Hypercholesterolemia. J Atheroscler Thromb. 2022 Jan 9. doi: 10.5551/jat.63151. Epub ahead of print. PMID: 35013021

Squier K, Scott A, Hunt MA, et al. The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study. PLoS One. 2021;16(9):e0257269. Published 2021 Sep 16. doi:10.1371/journal.pone.0257269

Baragetti A, Casula M, Scarinzi P, Ristè F, Scicali R, Biolo M, Lugari S, Dall'Agata M, Gazzotti M, Olmastroni E, Alieva AS, Nascimbeni F; ACTUS-FH LIPIGEN Substudy. Achilles tendon ultrasonography in familial hypercholesterolemia: A sub-study of the LIpid transPort disorders Italian GEnetic Network (LIPIGEN). J Intern Med. 2021 Dec 7. doi: 10.1111/joim.13421. Epub ahead of print. PMID: 34875114

Kitahara H, Nakayama T, Fujimoto Y, Kobayashi Y. Association between Achilles tendon xanthoma and severity of coronary artery disease in patients undergoing percutaneous coronary intervention. J Cardiol. 2020 Jun;75(6):654-658. doi: 10.1016/j.jjcc.2020.01.002. Epub 2020 Jan 25. PMID: 31992496

Sijbrands EJ. Xanthomas and atheromas. Atherosclerosis. 2017 Aug;263:315. doi: 10.1016/j.atherosclerosis.2017.06.003. Epub 2017 Jun 6. PMID: 28606368