Иммунофенотипические различия и остеобластная дифференцировка стволовых клеток жировой ткани
DOI:
https://doi.org/10.34687/2219-8202.JAD.2023.02.0001Ключевые слова:
стволовые клетки жировой ткани, остеогенная дифференцировка, иммунофенотип, гены остеогенеза.Аннотация
Благодаря набору уникальных свойств, например, способность дифференцироваться в различные типы клеток соединительной ткани мезенхимальные стволовые клетки привлекают все больше внимание исследователей. До настоящего времени большое число работ было посвящено изучению мезенхимальных клеток костного мозга. Однако не так давно в стромально-васкулярной фракции жировой ткани также обнаружили стволовые клетки, но в отличие от мезенхимальных клеток костного мозга они демонстрируют более высокую плотность в ткани, быстрее растут и доступны в большом количестве при сборе из небольшого объема жировой ткани. В результате в последнее время стволовые клетки жировой ткани становятся все более привлекательной и альтернативной популяцией мультипотентных клеток для исследования и для тканевой заместительной терапии. В этом обзоре мы подробно расскажем об иммунофенотепических особенностях мезенхимальных стволовых клетках жировой ткани, об влияние локализации и возраста на пролиферацию и дифференцировку стволовых клеток жировой ткани. Подробно остановимся на дифференцировке стволовых клеток в остеогенном направлении, как и по каким сигнальным путям, она идет, и какие факторы на нее влияют.
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Copyright (c) 2023 Е. Г. Учасова, Ю. А. Дылева, Е. В. Белик, О. В. Груздева
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